- David Genome
- David Ncifcrf
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David Genome
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David Ncifcrf
Functional Gene ClusteringGeneFunctional Classification Tool
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Read technical notes of the tool
Contact us for questions
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| What doesthistool do?
- Classify large gene list intofunctional related gene groups
- Rank the importance of thediscovered gene groups
- Summarize the major biology ofthe discovered gene groups
- Search other functionallyrelated genes from genome, but not in your list
- Visualize genes and theirfunctional annotations in a group by a single 2-D view
- Explore global view of genegroups in a Fuzzy Heat Map visualization
- More
The advantageof the tool:A novelgene-centricannotation approach - Your genes are highly organized sothat they are more readable and understanable.
- Your genes are ranked so that you canquickly focus on the most likely important ones.
- Your genes are displayed with theirannotation in one single view so that you can cross compare them.
- Your genes can be extended so thatyou have chance to know other functionally related genes, but not inyour list.
RationalConcepts: |
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| Fuzzy HeuristicPartition | | We developed a novelheuristic partitioning procedure that allows an object (gene) toparticipate in more than one cluster. The use of this method ingrouping related genes much better reflects the nature of biology inthat a given gene may be associated with more than functional group ofgenes. Two additional advancement included in this algorithm are: 1)the automatic determination of the optimal numbers of clusters (K), and2) the exclusion of members (genes) that have weak relationships toother members. Users are permitted tochange default parameters to set cluster membership similaritystringencies. Fuzzy Heuristic Partitioningof a gene list yields high quality clusters of highly related genes,with some genes participating in more than one function cluster. more |
| Grouping genesbased on functional similarity can systematically enhance biologicalinterpretation of large lists of genes derived from high throughputstudies. The Functional Classification Tool generates a gene-to-genesimilarity matrix based shared functional annotation using over 75,000terms from 14 functional annotation sources. Our novel clusteringalgorithms classifies highly related genes into functionally relatedgroups. Tools areprovide to furtherexplore each functional gene cluster including listing of the?consensus terms? https://torrent-mouse.mystrikingly.com/blog/hot-dice-slot-machine. shared by the genes in the cluster, display ofenriched terms, and heat map visualization of gene-to-termrelationships.A global view ofcluster-to-cluster relationships is provided using a fuzzy heat mapvisualization.Summary informationprovided by the Functional Classification Tool is extensively linked toDAVID Functional Annotation Tools and to external databases allowingfurther detailed exploration of gene and term information. Unreal tournament 2004 online. The FunctionalClassification Tool provides a rapid means to organize large lists ofgenes into functionally related groups to help unravel the biologicalcontent captured by high throughput technologies.more |
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